Ultrafine pulverization of traditional Chinese medicine is a new Chinese medicine processing technology that has emerged with the development of modern ultrafine powder technology. Ultrafine micronization of Chinese medicinal materials to achieve micron size, increasing cell wall breaking rate and specific surface area, thereby increasing the dissolution rate, bioavailability of active ingredients, reducing the amount of drug, and enhancing pharmacological effects, etc. The Chinese medicine industry has a wide range of concerns.
Supersonic jet pulverization technology is one of the main means of ultrafine pulverization. It combines multi-nozzle technology, fluidized bed technology and vortex grading technology according to aerodynamic theory to form a set of supersonic jet pulverization and grading. system. The working principle is that the purified and dried compressed air is introduced into a specially designed nozzle to form a supersonic flow, and enters the crushing chamber through several nozzles placed opposite to each other, and the material is sent from the hopper to the crushing chamber to be accelerated by the airflow of each nozzle, and impinges on the jet. The pulverization is realized at the intersection, and a high-speed two-phase fluidized bed is formed in the pulverizing chamber, and the powder collides with itself to achieve pulverization, and then is subjected to grading by a vortex high-speed classifier under the action of centrifugal force. The powder is pulverized and classified by air flow, and the particle size can reach the micron level.
The production operation of supersonic airflow crushing has the characteristics of sealing, instant, low temperature and physical process. The entire production process is carried out in a closed system, avoiding environmental pollution and reducing environmental pollution. Supersonic airflow pulverization, because the rapid expansion of air is an endothermic process, the entire pulverizing space is a low temperature environment, and the pulverization of the powder is instantaneously performed at a low temperature. Therefore, the phenomenon that the material generates heat during the pulverization process and destroys the chemical composition thereof is avoided, and is suitable for the pulverization of the heat sensitive and volatile component Chinese medicine. Jet pulverization is a purely physical act that does not cause any chemical reaction and thus maintains the original chemical properties of the material.
Chinese medicine formula granules are deep-processing products of traditional Chinese medicine decoction pieces. In view of the traditional use habits of some traditional Chinese medicines, such as powder swallowing or blistering, the use of supersonic airflow pulverization technology to prepare ultrafine powder of traditional Chinese medicine has a good prospect for improving the quality of traditional Chinese medicine formula. Jiangyin Tianjiang Pharmaceutical Co., Ltd. has carried out many years of exploratory research work in this area and achieved preliminary results. For the varieties of traditional Chinese medicine that are swallowed or washed, such as Sanqi, Fritillaria, Amber, Zihe, Tianma, Cordyceps, etc., these varieties are made into ultrafine powder, retaining the whole composition, and at the same time, due to cell wall rupture, All kinds of ingredients have been released, boiled water, quick onset, and high bioavailability. For some varieties with dense texture and low water extraction rate of active ingredients, such as alfalfa, ganoderma lucidum, sandalwood, etc., supersonic pulverization technology is used to make ultrafine powder, which improves the utilization rate of lycium polysaccharide and ganoderma lucidum polysaccharide, and better retains The characteristic aroma component of sandalwood. The application of supersonic airflow pulverization technology can also overcome the technical problems encountered in the preparation of traditional Chinese medicine formula granules by some varieties using traditional techniques. Such as a large amount of resin, gum frankincense, myrrh, a large amount of sugar and other varieties of hazelnuts, in the process of drying the concentrated liquid is easy to soften, stick to the wall, need to add a lot of excipients to complete the drying operation, resulting in the amount of consumption Big. Using the traditional pulverization technology, due to the large amount of heat generated during the pulverization process, the material is softened and adhered to the pulverizer blade and the screen, and the pulverization operation cannot be completed, and the low-temperature characteristics of the supersonic jet pulverization can overcome this drawback.
Supersonic jet milling technology provides a new means for the research and production of traditional Chinese medicine formula pellets, which has positive significance for saving and protecting Chinese herbal medicine resources and improving drug quality. The company's application research on this new technology mainly studies the particle size, uniformity, specific surface area, cell wall breaking rate, dissolution rate of some Chinese medicine ingredients, quality standards, etc. Although the toxicity reaction of ultrafine powder of traditional Chinese medicine has not been reported yet, the dissolution of active ingredients and other ingredients is simultaneously increased due to the high dissolution rate of ultrafine powder of traditional Chinese medicine. Due to safety considerations, this technology has not been widely used in the production of traditional Chinese medicine formula particles. . In the future, it is necessary to strengthen the in-depth study on drug safety and carry out dose conversion studies on ultrafine powder and traditional decoction. At present, Jiangyin Tianjiang Pharmaceutical Co., Ltd. has organized relevant research institutes to jointly tackle the problem and apply supersonic airflow smashing technology to improve the quality of traditional Chinese medicine formula granules.
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