For the first time in the world, Korean research institutes have successfully bred genetically modified fluorescent chickens, making the application of genetically modified eggs a step closer to large-scale applications in food and pharmaceutical industries. Kim Tae, a professor at the Medical College of Daegu Christian University, announced the results on the 12th. The fluorescent pheasant was implanted with jellyfish green fluorescent protein (GFP) in vivo, which was similar to other chickens in normal light. Under ultraviolet light, the mouth and feathers emitted bright green fluorescence. Professor Jin said that GFP showed some toxicity in the hatching process of chickens and affected the development of the embryos. The successful transgenic chickens were the first in the world. The GFP gene is a marker gene, and the species carrying the gene will fluoresce. GFP is often implanted with the functional species of other species in the cells of the test species. If a fluorescence reaction occurs in a new species derived from the transgene, the genes of other species that are simultaneously implanted with GFP should also be present in the cells of the transgenic species. As a key part of the entire experiment, the researchers completed the development of retroviral vectors, which enabled the implantation of the GFP gene. Due to the restricted egg structure of poultry, the success rate of this technology is currently very low. The researchers said that the chicken's incubation period is 21 days, the reproductive cycle is 6 months, and the price is low, which is suitable as a genetically modified experimental object. Moreover, since there are only 8 proteins that make egg albumen, genetically engineered proteins are easily separated from the components of the egg. It is expected that eggs can be used to produce large quantities of proteins required by the pharmaceutical industry. The Zhongnan University Transgenic Cloning Pig Research Center, Prof. LI Xunze’s Research Group of Jianguo University, and the Dr. Zhang Yuanjing Research Group of the Animal Husbandry and Technology Research Institute jointly conducted the study.
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