How to configure a GMP-compliant bottling line

A bottling and packaging line that conforms to GMP standards and is perfect. In addition to high automation, stable and reliable product performance, convenient operation and maintenance, and exquisite appearance, every station on the line must have online inspection to ensure that no one is allowed. The sly products flow to the next step to ensure that every product down the production line is perfect.

Solid preparation bottle packaging line is generally made up of bottle unscrambler, bottle washer, metering filling machine, (paper, cotton wool, desiccant) stuffing machine, capping machine, aluminum foil sealing machine, labeling machine, medicine bottle cartoning machine and automatic inspection. Heavy scale and other components.

In order to facilitate the reader to have a preliminary understanding of the packaging line, it is possible to meet the actual needs and correctly configure an efficient and reasonable packaging line. Here, the author gives a brief introduction to the functions and features of each main station of the packaging line, hoping to help the reader in the selection of solid preparation bottle packaging line.

Packing line * The station is a bottle, the bottle unloading machine can automatically complete the bottle-receiving function, automatically arrange the messy plastic bottles into the bottle mouth, and feed them neatly into the conveyor line, and enter the next process. According to the speed of the bottle, it can be divided into a medium speed bottle machine and a high speed bottle machine. For the medium speed bottle machine with low production speed requirement (60 metering and bottling is the core of the whole packaging line, the metering bottling equipment currently available in the market can be divided into volumetric bottling machine and several-pack method. There are two types of bottle machines, and the number of bottling machines can be divided into mechanical template granulators and electronic counting machines. Volumetric filling is generally used in traditional Chinese medicine factories, and most pharmaceutical companies use several tablets. Method filling.

The mechanical template granulator has advantages in a single production condition. The machine uses a uniquely designed template to not only automate the filling of tablets and pills, but also for shaped tablets and soft. Hard capsules are automatically counted and bottled. In order to improve the accuracy of the number of particles, in recent years, "Noah Company" has added a detection system on the machine, and through the automatic detection of scanning in the production process, it is found that the lack of grain condition can be replenished in time by the filling device, and the number of particles is extremely accurate. At present, the machine can achieve high speed and free filling. For users who produce low-end products, this machine is cheap and good.

At present, the multi-channel electronic counting machine is popular. The medicine is subjected to multiple orbital three-stage vibration feeding, and the particles are detected and counted according to the principle of photoelectric induction, and the number of particles is extremely accurate. The machine has strong adaptability, no need to replace any molds for changing varieties and specifications, users can easily complete the variety replacement through simple setting on the touch screen, and can adapt to various single-bottle contents and dosage forms. It is widely welcomed because of its accurate counting, number of particles and fast bottling speed. In the past few years, “Noah Company” has spent a lot of effort on this machine. Through a large amount of capital investment and painstaking research, it has made a key breakthrough in some technical difficulties, and it can compete with similar foreign technology and is already on the market. Very good results have been achieved. This machine has become the fist product of Noah Company and has been exported to Europe, North America, Oceania and Southeast Asia, and is favored by foreign businessmen.

In order to ensure that the drug remains intact and prolongs the shelf life during storage and transportation, it is generally necessary to add a corresponding filler to the vial, such as a paper or cotton that is inserted into the shockproof. In order to prevent the drug from being deteriorated by moisture, the desiccant must be inserted. These are all important processes in pharmaceutical and food packaging.

We specially designed and produced the paper jammer and cotton plug machine for this purpose, adopting the novel high-precision electronic positioning system, flexible start, fast speed, low noise and reliable positioning. Apply the electronic pulse to set the length of each roll and cotton pull, automatically cut and pour into the bottle. The "Noah Company" plugging paper and the cotton plug machine are produced with a special feature, which can prevent the paper edges and cotton buds from sticking out of the bottle, affecting the next process of capping and sealing. Similarly, the “Norya Company” desiccant plug-in machine has special photoelectric positioning, servo motor drive, and intelligent control of the feeding length to accurately and quickly cut the strip-shaped bag desiccant automatically and automatically into the container. The machine has the function of preventing the cutting of the bag and automatically detecting the empty package of the strip-shaped desiccant, and the problem can be immediately stopped, ensuring that the product produced by the user does not have a quality accident due to the above reasons.

In order to form a basic bottle line of Zui, the capping machine is indispensable. At present, there are two types of automatic capping machines available on the market, which are divided into working forms, claw-type capping machines and squeezing machines. Cover the machine. The basic functions of the two are roughly the same, and the cover and the cap can be automatically completed. The former has a relatively slow production speed, and because of the different specifications of the caps, different robots (claws) need to be replaced, and the advantage is that the price is relatively low. The latter only needs to be easily adjusted due to the replacement of specifications, and the production speed is fast, which can meet the demand of high-speed lines. The user has widely adopted "Noah Company" to ensure the quality of the screw cap, and a series of measures have been taken on the capping machine. If the bottle is automatically capped after entering the station, the cap will be flattened by the capping device, and then the capping mechanism consisting of three pairs of capping wheels will be fed to ensure that the caps of different shapes can be tightened, in accordance with the standard. Once the screw cap is found to be tight or not covered, it can be automatically detected and rejected.

In order to ensure that the drug remains intact and prolongs the shelf life, in addition to the desiccant, paper or cotton in the bottle, aluminum foil sealing is generally used to prevent the drug from getting wet. The problems that need to be paid attention to when choosing an electronic induction sealing machine are: high-power magnetic field and radiation, interference to other equipment and personal injury. "Noah Company" aluminum foil sealing machine uses composite electromagnetic induction sealing technology, adopts intermediate frequency power supply, has high effective output power, adjustable output current and will automatically change with load change. It can automatically stand by without bottle to save energy. . The special induction board has good shielding and cooling conditions, so the bonding time is short, the fastness is strong, the speed is fast, the operation is simple, the performance is stable, and the bottle mouth can be reliably sealed when it is stained with various liquids. The machine can automatically detect bottles without aluminum foil and remove them in time. Due to the use of intermediate frequency power supply and reliable shielding measures, it will not only interfere with the stable operation of other equipment, but also ensure that operators who work long-term on the production line will not be affected by radiation and affect health.

After the drug is packaged, the bottle needs to be labeled. According to the different needs of users, paste labeling machines and self-adhesive labeling machines can be arranged on the packaging line. However, most of the users in the near future generally use self-adhesive labeling machines. The self-adhesive labeling machine produced by Noah Company can be divided into a circumferential sticker, a side sticker, a double-sided sticker, etc., which can automatically complete the separation and delivery of the label, and the date on which the hot print is clearly written on the label. Batch number, synchronous separation label, labeling series program.

The equipment adopts electromechanical integration technology, featuring high sensitivity, stable speed and strong anti-interference ability. Ensure that the standards are consistent, stable, reliable and efficient. Broken labels, no labels, missing codes, and leak labels can automatically alarm. In particular, the double-sided labeling machine produced by Noah Company has been praised by users at this year's Chengdu meeting due to the adoption of special technology and the standard of labeling, stability and reliability. Among them, a pharmaceutical factory in Guizhou holds an oval flat bottle and requires labeling on both sides of the bottle. At the show, they tried the results on the labeling machines provided by all the suppliers. The result is: "Only your labeling machine works well"

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Rushan Jinguo Food Co., Ltd , https://www.jinguofood.cn